mif - An Overview
mif - An Overview
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Also, glucocorticoids also promote white blood cells to release MIF and consequently MIF partly counteracts the inhibitory consequences that glucocorticoids have around the immune method. lastly trauma activates the anterior pituitary gland to launch MIF.[11]
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The receptor that mediated MIF exercise remained elusive until finally a research in 2003, which utilized a cDNA library and fluorescently conjugated MIF to screen for the receptor and discovered CD74 as being the MIF receptor. The authors explained that MIF sure to the extracellular area of CD74, causing extracellular sign-controlled kinase (ERK) pathway activation (25).
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